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Scientific Advisory Board
Douglas A. Melton, Ph.D. (Chairman of Advisory Board)
Investigator, Howard Hughes Medical Institute
Professor, Department of Molecular and Cellular Biology
Harvard University
Dr. Melton is also Thomas Dudley Cabot Professor in the Natural
Sciences at Harvard University and Research Associate at Children’s
Hospital and Massachusetts General Hospital, Boston. He received
a B.S. degree in biology from the University of Illinois, Urbana,
and a B.A. degree in history and philosophy of science from Cambridge
University, England. His Ph.D. Degree in molecular biology is from
the Medical Research Council Laboratory of Molecular Biology in
Cambridge and Trinity College, Cambridge. He has served on the editorial
boards of several scientific journals. Dr. Melton is a member of
the National Academy of Sciences and the Institute of Medicine,
part of the National Academies.
Brigid Hogan, Ph.D.
George Barth Geller Professor and Chair, Department of Cell Biology
Duke University Medical School
Dr. Hogan is considered a world leader in developmental biology
and stem cell research. She is a member of the Institute of Medicine
of the National Academy of Sciences, a fellow of the American Academy
of Arts and Sciences, and a fellow of the Royal Society of London,
among other prestigious groups. She was the scientific co-chair
of the 1994 National Institutes of Health report on human embryo
research. More recently, she has been named chair of the Department
of Cell Biology at Duke University Medical Center (DUMC). She is
the first woman to be appointed chair of a basic science department
at DUMC. She previously served as director of the Stem Cell and
Organogenesis Program at Vanderbilt University Medical Center in
Nashville.
Thomas Jessell, Ph.D.
Investigator, Howard Hughes Medical Institute
Professor, Center for Neurobiology and Behavior
Columbia University, College of Physicians and Surgeons
Dr. Jessell received his undergraduate education at the University
of London and went on to get a master’s degree at London Hospital.
He earned his Ph.D. in neuropharmacology from Cambridge University.
He was a post-doctoral fellow at Harvard Medical School, a Locke
Research Fellow of the Royal Society and an Assistant Professor
in the Department of Neurobiology at Harvard Medical School. He
later moved to Columbia University College of Physicians and Surgeons,
where he also became an Investigator at the Howard Hughes Medical
Institute, and since 1989 has been Professor of Biochemistry and
Molecular Biophysics at the Center for Neurobiology and Behavior
at Columbia. Dr. Jessell is a Fellow of the Royal society of London,
a foreign associate of the US National Academy of Sciences, a member
of the Institute of Medicine, and a Fellow of the American Academy
of Arts and Sciences. His work helped elucidate the role sonic hedgehog
plays in the development and differentiation of the spinal cord
and nervous system.
Andrew P. McMahon, Ph.D.
Frank B. Baird, Jr. Professor of Science,
Chairman, Department of Molecular and Cellular Biology
Harvard University
Dr. McMahon received a B.A. in Zoology from St. Peter’s College,
Oxford University and a Ph.D. from University College in London.
He was a Postdoctoral Fellow at the California Institute of Technology
in the Division of Biology and later a Staff Scientist at the National
Institute for Medical Research in London. Dr. McMahon served as
Adjunct Professor In the Department of Genetics and Biological Sciences
at Columbia University and as a Full Member of the Department of
Cell and Developmental Biology at the Roche Institute of Molecular
Biology before he became Professor of Molecular and Cellular Biology
at Harvard University in 1993 and Chairman of the Department in
2001. He is also an Associate Member of the European Molecular Biology
Organization. He is a co-discoverer of the vertebrate Hedgehog,
and his developmental genetic studies on Wnt and Hedgehog signaling
have led to many key insights into the roles of these signals in
a wide-range of developmental processes. In 2003, he was elected
Fellow of the American Academy of Arts and Sciences.
Roeland Nusse, Ph.D.
Professor of Developmental Biology
Investigator, Howard Hughes Medical Institute
Stanford University Medical School
Dr. Roel Nusse obtained his PhD in the Netherlands, working at the
Netherlands Cancer Institute. He did postdoctoral work at UCSF between
1981-1982, with Dr. Harold Varmus. After returning to the Netherlands,
Dr. Nusse rose from staff member to head of the Department of Molecular
Biology at the Netherlands Cancer Institute in Amsterdam. He joined
Stanford in 1990 as Associate Professor of Developmental Biology
and was at the same time appointed as a Howard Hughes Medical Institute
Investigator. He became Full Professor in 1994 and served as Chair
of the Department of Developmental Biology from 1999-2003.
During his career, Dr. Nusse has made several of the most important
discoveries regarding Wnt signaling, now recognized as a key player
in various cancers, including human colon cancer. Dr. Nusse was
elected to the Royal Dutch Academy of Science in 1997 and the American
Academy of Arts and Sciences in 2001.
Martin C. Raff, M.D.
Professor, Department of Biology
MRC Laboratory For Molecular and Cell Biology
University College London
Dr. Raff was born and educated in Montreal and received his B.Sc.
and M.D. degree from McGill University. He then pursued residencies
in medicine at the Royal Victoria Hospital in Montreal and in neurology
at Massachusetts General Hospital in Boston. Dr. Raff completed
his postdoctoral training in immunology at the National Institute
for Medical Research in London, after which he moved to University
College London and has been a Professor of Biology since 1979. He
is a Fellow of the Royal Society and the Academia Europaea, a foreign
member of the American Academy of arts and Sciences and of the National
Academy of Sciences, and is past president of the British Society
of Cell Biology. Research interests span immunology, cell biology
and developmental neurobiology.
Matthew Scott, Ph.D.
Professor, Department of Developmental Biology & Genetics
Investigator, Howard Hughes Medical Institute
Chairman, Bio-X Scientific Leadership Council
Stanford University School of Medicine
Dr. Scott is a Professor of Developmental Biology and Genetics and
a Howard Hughes Medical Institute Investigator. He received his
BS and PhD from the Massachusetts Institute of Technology and did
his postdoctoral fellowship at Indiana University. He joined the
Stanford faculty in 1990 after spending seven years on the faculty
of the University of Colorado at Boulder. He was named a Howard
Hughes Medical Institute investigator in 1993. Dr. Scott served
as chair of the Department of Developmental Biology from January
1996 to January 1999 and then for three years as associate chair.
In 2002 he was appointed Chair of the Bio-X Leadership Council.
Dr. Scott has received numerous honors and awards, including the
American Cancer Society Junior Faculty Research Award, the Passano
Foundation Young Investigator Award, and the National Institutes
of Health Research Career Development Award. He was named a fellow
of the American Academy of Arts and Sciences in 1996 and was elected
to the National Academy of Sciences in 1999.
Clifford J. Tabin, Ph.D.
Professor, Department of Genetics
Harvard Medical School
Dr. Tabin is Professor of Genetics at Harvard Medical School and
Adjunct Professor of Health Sciences and Technology at the Massachusetts
Institute of Technology. He received his Ph.D. in Biological Sciences
at MIT in 1984 and did postdoctoral fellowships at the Department
of Biochemistry at Harvard University and the Department of Molecular
Biology at Massachusetts General Hospital before joining the faculty
at Harvard Medical School in 1989. His research on the genetic basis
for embryological development has been widely recognized, and he
won the National Academy of Sciences Award in Molecular Biology
in 1999. He was also elected to the American Academy if Arts and
Sciences in 2000.
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